PubMed的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列免費下載的地點或者是各式教學

Handbook of Proteolytic Enzymes: Serine and Threonine Peptidases

為了解決PubMed的問題，作者 這樣論述：

The Handbook of Proteolytic Enzymes has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new, fourth edition is an essential reference for biochemists, biotechnologists, and molecul

ar biologists across academia and industry. Edited by world-renowned experts in the field and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases

, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes. This volume, Serine and Threonine Peptidases, includes over 400 chapters on known serine and threonine peptidases, including their name, history, activity and specificity, structural chemistr

y, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決PubMed的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Human Medical Thermography

為了解決PubMed的問題，作者Campbell, James Stewart,Mead, M. Nathaniel 這樣論述：

Dr James Stewart Campbell received his bachelor’s degree in Electrical Engineering from Lehigh University in 1966, and then went on to study medicine at the Albany Medical College in Albany, NY, receiving his MD degree in 1970. After completing a straight-surgical internship at the University of Was

hington, he helped found The Country Doctor Clinic in Seattle and practiced general medicine there until 1975. In 1976, Dr. Campbell sfounded the nonprofit Mountain Peoples’ Clinic and had a successful practice of general medicine. He also taught electronics at Tri-County Community College in Murphy

, NC.Dr. Campbell took a leave from clinical medicine in 1986 to work in biomedical engineering, specializing in biological-to-electronic interfacing. His design projects have included air plethysmography, non-invasive blood pressure devices, ultrasound imaging and flowmeters, photo-plethysmography,

fluorescence microscopy, bio-impedance, bio-acoustics, intra-cardiac sensor-stimulators, and implantable neural probe systems.In 2010, Dr. Campbell started a thermography service for Integrative Life Solutions Inc. in Clemmons, NC. Over the next 7 years, the practice became a successful provider of

general and breast thermography. After retiring from medical practice in 2017, he assembled the wealth of objective thermal data from the service into a huge spreadsheet derived from over one thousand imaging sessions. These thermal images and numerical data, along with much additional research and

writing help of his co-author, form the foundation of this book. Dr. Campbell lives in Pfafftown, North Carolina. He is a Life Senior Member of the Institute of Electrical and Electronic Engineers (IEEE), and a Senior Member of the American Academy of Thermology (AAT).M. Nathaniel Mead, MSc, earned

his master’s degree in Nutritional Epidemiology from the UNC Gillings School of Global Public Health. Through his work as a medical-scientific writer, he has over 40 scientific articles listed on PubMed, including papers published in the International Journal of Cancer, Journal of the National Canc

er Institute, Integrative Cancer Therapies, Environmental Health Perspectives, and Cancer Treatment Reviews. In addition to nine years as a contributing editor to Natural Health magazine, Mead served for 20 years as an editorial board member for Integrative Cancer Therapies (Sage Publications) and a

s a research associate for the Block Center for Integrative Cancer Treatment in Skokie, Illinois. He underwent clinical training in thermography under his coauthor and has lectured at the annual scientific session of the American Academy of Thermology.

成人生命意義感與復原力之關係：以制握信念為調節變項

為了解決PubMed的問題，作者李育慈 這樣論述：

　　本研究主要目的在探究成人生命意義感（涵蓋存在意義感與尋找意義感二向度）與復原力之關係，並檢視制握信念在二者關係的調節效果，以網路問卷蒐集資料，研究參與者為401位台灣地區成人，年齡涵蓋18至65歲。研究重要結果摘要分析如下：一、生命意義感對復原力之預測力發現：對全體成人而言，生命意義感二個向度（存在意義感、尋找意義感）皆可以顯著預測復原力，其中：成人的存在意義感程度越高，其復原力程度越高；但成人的尋找意義感程度越高，其復原力的程度越低。然而，此結果尚未考量制握信念為調節變項產生不同結果之影響。二、制握信念之調節變項效果發現：（1）無論「內部制握信念組」、「無顯著制握信念組」及「外部制握信

念組」的成人，其存在意義感皆能正向預測復原力，並且，「內部制握信念組」（β = .45）與「外部制握信念組」（β = .42）的成人，其存在意義感對於復原力的預測力高於「無顯著制握信念組」（β = .29）的成人。（2）在「無顯著制握信念組」（β = -.20）與「外部制握信念組」（β = -.25），成人尋找意義感對於復原力有負向預測效果，但在「內部制握信念組」，成人尋找意義感無法顯著預測復原力。　　本研究發現成人生命意義感（存在意義感、尋找意義感）對於復原力的預測力，會因為制握信念傾向的不同而有不同之預測力，此結果對成人輔導實務工作有臨床之貢獻。