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非家族總裁繼任後，董事會權力和高階管理團隊重組如何影響家族先前不佳的企業績效：以台灣家族企業為例

為了解決Small and medium siz的問題，作者陳廷晞 這樣論述：

To explore a better corporate governance mechanism in Taiwan, the object of this study is to analyze how non-family CEO succession, TMT restructuring and board power will influence family businesses’ performance after the poor performance occurred in the family business. This Master’s Thesis’ main

assumption are as follows: When a poor performance occurs in family businesses, a family business is likely to appoint a non-family CEO; Hiring a new non-family CEO after a poor performance occurred in family businesses will have a positive effect on corporate performance in terms of financial perfo

rmance; The restructuring of top management team will influence the family businesses’ performance positively in terms of financial performance after CEO succession; Board power can moderate corporate performance after the non-family CEO succession. The higher level the family control is (more insid

e directors involved in the board), the higher degree the board intervene the management decision will be, and the lower the performance will increase.This study contributes to family business, strategic management, and corporate governance research by suggesting the following three results. First,

a family corporate is likely to appoint a non-family CEO when a poor performance occurs. This finding assures that as an outsider who has more managerial skills, capabilities, knowledge, and competencies can overcome the difficulties and influence the corporate’s development positively especially in

terms of financial performance. Second, board power can moderate corporate performance after the non-family CEO succession in family business. Though the finding is different from the prior research which indicate that the rise of the degree of “board independence” may influence corporate’s perform

ance positively. However, the third finding shows that the higher level the family control is (the more inside directors involved in the board), the higher degree the board intervene the management decision will be, and the lower the performance will increase. The result of the moderating effect on

non-family CEO and board power indicates that board power and board independence is crucial on moderating the succession in family business.

探討小泛素化修飾於YB-1引發錯配位修補缺失之調節性角色

為了解決Small and medium siz的問題，作者鄭儀 這樣論述：

中文摘要 i英文摘要(Abstract) ii目錄 iii附表與附圖目錄 vi壹、 緒論 1一、 Y-box binding protein 1 (YB-1) 1(一) YB-1之結構介紹 1(二) YB-1調控細胞中之生理功能 2(1) YB-1參與基因轉錄(Transcription) 2(2) YB-1參與DNA修復(DNA repair) 3(3) YB-1參與蛋白質轉譯(Translation) 3(4) YB-1之轉譯後修飾(Post-translational mo

dification) 4(三) YB-1作為致癌基因在癌症中的影響 5二、 Small Ubiquitin-like Modifier (SUMO) 6(一) SUMO之家族成員 6(二) SUMO之循環修飾反應 7三、 錯配位修補(Mismatch repair, MMR) 8(一) 參與錯配位修補之相關蛋白質 8(二) 錯配位修補機制與生理功能 9(三) 錯配位修補在癌症中之重要性 10貳、 研究目的與策略 12參、 實驗材料與方法 14一、 實驗材料

141、 菌種(Bacteria strain) 142、 質體(Plasmid) 143、 細胞株(Cell line) 214、 培養液與培養基(Bacterial broth and cell culture medium) 215、 溶液(Buffer and solution) 226、 抗體(Antibody) 257、 化學藥品(Chemical and reagent) 258、 引子(Primer) 25二、 實驗方法 261、 質體轉型(Transformat

ion) 262、 質體製備(Plasmid preparation) 26(1) 小量製備(Mini-preparation) 26(2) 中量製備(Midi-preparation) 263、 質體核酸點定位點突變(Site-directed mutagenesis) 274、 細胞培養(Cell culture) 295、 細胞轉染(Transfection)-磷酸鈣共沉澱法(calcium-phosphatecoprecipitation) 296、 SDS-聚丙烯醯胺凝膠製備和電泳(SDS polya

crylamide gel preparationand electrophoresis) 297、 西方墨點法(Western blot) 308、 GST融合蛋白質之純化(Purification of GST fusion protein) 319、 In vivo SUMO分析(In vivo SUMO assay) 3210、 In vitro SUMO分析(In vitro SUMO assay) 3211、 YB-1及其突變蛋白表現過量細胞株之建立(Construct overexpressingcell line of

YB-1 and it mutants) 3312、 免疫螢光染色分析(Immunofluorescence analysis) 3313、 Luciferase冷光酵素檢測法(Luciferase assay) 3414、 共同免疫沉澱檢測法(Co-immunoprecipitation assay) 3415、 DNA-蛋白質結合試驗(DNA pull-down assay) 35肆、 實驗結果 36一、 YB-1胺基酸位置Lys26/301/304是YB-1 SUMOylation修飾重要的位置 36二、

YB-1可以在細胞外被SUMOylation修飾，並且受到SUMO-1、SUMO-2以及SUMO-3不同程度的修飾作用 37三、 YB-1之SUMOylation對於細胞中的分布位置與穩定性影響之探討 38四、 YB-1之SUMOylation對於MDR-1基因轉錄活性影響之探討 39五、 YB-1之Lys26/301/304 SUMOylation對於YB-1與PCNA親和力之活性相當重要 39六、 YB-1之Lys26 SUMOylation對於MutSα/PCNA結合活性以及MutSα辨識並結合至錯配位點之活性相當重要 40伍、

討論 42一、 YB-1之Lys26是主要YB-1 SUMOylation位置，而Lys301/304則是次要位置 42二、 YB-1被SUMO修飾的位置不具有ΨKxE/D特徵 43三、 YB-1的SUMOylation不影響YB-1在細胞中分布的位置、蛋白質穩定性以及轉錄因子轉活化活性 43四、 SUMO似乎可以作為YB-1與PCNA相互作用之媒介物 44五、 YB-1之Lys26 SUMOylation對於MutSα/PCNA複合物形成以及Mutsα辨識並結合至錯配位點之活性相當重要 44陸、 參考文獻 4

6柒、 附表與附圖 52